α-Perfluoroalkyl-β-alkynylation of alkenes via radical alkynyl migration† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc02175e

Palladium-catalyzed cross-coupling of α-bromocarbonyls and allylic alcohols for the synthesis of α-aryl dicarbonyl compounds† †Electronic supplementary information (ESI) available. CCDC 1042318. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5sc00505a

The palladium-catalyzed coupling of olefins and organohalides is a versatile approach for synthesizing complex molecules from simple starting materials. We have developed a palladium-catalyzed coupling of α-bromocarbonyl compounds with allylic alcohols for the generation of acyclic aryl-substituted dicarbonyl compounds. The reaction proceeds via a tandem olefin insertion of an α-acyl radical fo...

Metalloradical activation of α-formyldiazoacetates for the catalytic asymmetric radical cyclopropanation of alkenes† †Electronic supplementary information (ESI) available. CCDC 1532256. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc00658f Click here for additional data file. Click here for additional data file.

For the first time, a-formyldiazoacetates have been successfully applied for the asymmetric cyclopropanation of alkenes via Co(II)-based metalloradical catalysis. The cobalt(II) complex of the D2symmetric chiral amidoporphyrin [Co(3,5-DiBu-ChenPhyrin)] is an effective metalloradical catalyst that can activate a-formyldiazoacetates to cyclopropanate both aromatic and aliphatic olefins with varie...

Copper-catalyzed aminoalkynylation of alkenes with hypervalent iodine reagents† †Electronic supplementary information (ESI) available: Characterization data and experimental procedures. CCDC 1567005–1567007. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc03420b

A copper-catalyzed aminoalkynylation of alkenes is achieved with ethynylbenziodoxolone (EBX) reagents under mild conditions with only 1 mol% copper catalyst. This transformation allows for rapid construction of diverse important azahetereocycles and installation of valuable alkyne groups in one step. The developed method features remarkable substrate scope for both terminal and internal alkenes...

Phosphine-catalyzed enantioselective [3 + 2] cycloadditions of γ-substituted allenoates with β-perfluoroalkyl enones† †Electronic supplementary information (ESI) available: Experimental details, analytical data, NMR spectra of products. CCDC 1503840 (3aa). For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc01432e Click here for additional data file. Click here for additional data file.

Room temperature decarboxylative cyanation of carboxylic acids using photoredox catalysis and cyanobenziodoxolones: a divergent mechanism compared to alkynylation† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc04907a Click here for additional data file.